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Article

Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.

The Journal of experimental medicine - 16 Apr 2007

Crozat Karine, Hoebe Kasper, Ugolini Sophie, Hong Nancy A, Janssen Edith, Rutschmann Sophie, Mudd Suzanne, Sovath Sosathya, Vivier Eric, Beutler Bruce

Abstract excerpt

Mouse cytomegalovirus (MCMV) susceptibility often results from defects of natural killer (NK) cell function. Here we describe Jinx, an N-ethyl-N-nitrosourea-induced MCMV susceptibility mutation that permits unchecked proliferation of the virus, causing death. In Jinx homozygotes, activated NK cells and cytotoxic T lymphocytes (CTLs) fail to degranulate, although they retain the ability to produce cytokines, and...

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Identifiers

PMID: 17420270
DOI: 10.1084/jem.20062447
PMCID: PMC2118559

Genes

FHL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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