Gene-corrected human Munc13-4–deficient CD8+ T cells can efficiently restrict EBV-driven lymphoproliferation in immunodeficient mice

Abstract excerpt

To the editor: Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) is a hyperinflammatory disease caused by mutations in the UNC13D gene (coding for the Munc13-4 protein); FHL3 accounts for 30% to 35% of FHL cases.[1][1] In cytotoxic T cells (CTLs) and natural killer cells, Munc13-4 helps to

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