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Article

Matrix metalloproteinase-2 (-1306 c>t) promoter polymorphism and risk of colorectal cancer in the Saudi population.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Saeed Hesham Mahmoud, Alanazi Mohammad Saud, Parine Narasimha Reddy, Shaik Jilani, Semlali Abdelhabib, Alharbi Othman, Azzam Nahla, Aljebreen Abdulrahman, Almadi Majid, Shalaby Manal Aly

Abstract excerpt

BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), results in strikingly lower promoter activity with the T allele. In the present study, we investigated whether this MMP-2 genetic polymorphism might be...

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PMID: 24289619
DOI: 10.7314/apjcp.2013.14.10.6025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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