Sickle cell trait and incident ischemic stroke in the Atherosclerosis Risk in Communities study.

doi:10.1161/STROKEAHA.114.006110

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Article

Sickle cell trait and incident ischemic stroke in the Atherosclerosis Risk in Communities study.

Stroke - 1 Oct 2014

Caughey Melissa C, Loehr Laura R, Key Nigel S, Derebail Vimal K, Gottesman Rebecca F, Kshirsagar Abhijit V, Grove Megan L, Heiss Gerardo

Abstract excerpt

BACKGROUND AND PURPOSE: Numerous case reports describe stroke in individuals with sickle cell trait (SCT) in the absence of traditional risk factors for cerebrovascular disease. To date, no prospective epidemiological studies have investigated this association. METHODS: A population-based sample of blacks (n=3497; mean age=54 years; female=62%) was followed from 1987 to 2011 in the Atherosclerosis Risk in...

Topics

Black or African American
Aged
Atherosclerosis
Cohort Studies
Female
Genotype
Humans
Incidence
Male
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
Risk Factors
Sickle Cell Trait
Stroke

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PMID: 25139879
DOI: 10.1161/STROKEAHA.114.006110
PMCID: PMC4174726

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