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Article

Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations.

AIDS (London, England) - 30 Mar 2007

Frankel Fernando A, Invernizzi Cédric F, Oliveira Maureen, Wainberg Mark A

Abstract excerpt

OBJECTIVES: To determine the underlying biochemical mechanisms responsible for the diminished viral replicative capacity associated with K65R/M184V-containing viruses. METHODS: We studied the efficiency of (-)ssDNA synthesis by recombinant wild-type and mutated HIV-1 reverse transcriptases in cell-free assays. In addition, we determined susceptibility levels to nucleoside analog reverse transcriptase inhibitors...

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Identifiers

PMID: 17413687
DOI: 10.1097/QAD.0b013e3280187505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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