Article
Negative effect of the M184V mutation in HIV-1 reverse transcriptase on initiation of viral DNA synthesis.
Virology - 20 Jun 2003
Wei Xin, Liang Chen, Götte Matthias, Wainberg Mark A
Abstract excerpt
The M184V mutation in HIV reverse transcriptase (RT) is associated with high-level resistance against the nucleoside inhibitor lamivudine as well as diminished viral replication capacity. We have previously demonstrated that HIV variants containing the M184V mutation were relatively unable to successfully undergo compensatory mutagenesis following deletion of an A-rich loop located upstream of the primer binding...
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