Article
The processivity of DNA synthesis exhibited by drug-resistant variants of human immunodeficiency virus type-1 reverse transcriptase.
Nucleic acids research - 1 Apr 1998
Avidan O, Hizi A
Abstract excerpt
The reverse transcriptase (RT) of human immunodeficiency virus (HIV) undergoes rapid mutagenesis due to selective pressure by RT inhibitors which renders the mutated RT variants resistant to these inhibitors. Resistance to nucleoside analogs during drug therapy results from point mutations that l...
Topics
- Cloning, Molecular
- DNA, Viral
- Drug Resistance, Microbial
- Escherichia coli
- Genetic Variation
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Kinetics
- Mutagenesis, Site-Directed
- Point Mutation
- Recombinant Proteins
- Reverse Transcriptase Inhibitors
- Selection, Genetic
- Templates, Genetic