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Article

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

Antiviral chemistry & chemotherapy - 1 Jan 2007

Ly John K, Margot Nicolas A, MacArthur Holly L, Hung Magdeleine, Miller Michael D, White Kirsten L

Abstract excerpt

The HIV-1 reverse transcriptase (RT) resistance mutations K65R and M184V occur individually and in combination, and can contribute to decreased treatment responses in patients. In order to understand how these mutations interact with one another to confer drug resistance, the susceptibilities and underlying resistance mechanisms of these mutants to nucleoside RT inhibitors (NRTIs) were determined. Virus carrying...

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Identifiers

PMID: 18320935
DOI: 10.1177/095632020701800603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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