Article
The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses.
AIDS (London, England) - 6 Dec 2002
Wei Xin, Liang Chen, Götte Matthias, Wainberg Mark A
Abstract excerpt
OBJECTIVE: To study the ability of HIV constructs containing the M184V substitution in reverse transcriptase (RT), which causes resistance to lamivudine, to evolve mutations that compensate for deletions within the HIV genome. METHODS: Viruses containing deletions in non-coding regions of the viral genome were examined in tissue culture to see whether the additional presence of M184V delays the reestablishment of...
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