Article
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations.
The Journal of biological chemistry - 2 Jan 2004
Deval Jérôme, White Kirsten L, Miller Michael D, Parkin Neil T, Courcambeck Jérôme, Halfon Philippe, Selmi Boulbaba, Boretto Joëlle, Canard Bruno
Abstract excerpt
HIV-1 drug resistance mutations are often inversely correlated with viral fitness, which remains poorly described at the molecular level. Some resistance mutations can also suppress resistance caused by other resistance mutations. We report the molecular mechanisms by which a virus resistant to lamivudine with the M184V reverse transcriptase mutation shows increased susceptibility to tenofovir and can suppress...
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