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Article

Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.

Science (New York, N.Y.) - 6 Apr 2007

Liu Sunbin, Li Ping, Dybkov Olexandr, Nottrott Stephanie, Hartmuth Klaus, Lührmann Reinhard, Carlomagno Teresa, Wahl Markus C

Abstract excerpt

Although highly homologous, the spliceosomal hPrp31 and the nucleolar Nop56 and Nop58 (Nop56/58) proteins recognize different ribonucleoprotein (RNP) particles. hPrp31 interacts with complexes containing the 15.5K protein and U4 or U4atac small nuclear RNA (snRNA), whereas Nop56/58 associate with 15.5K-box C/D small nucleolar RNA complexes. We present structural and biochemical analyses of hPrp31-15.5K-U4 snRNA...

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PMID: 17412961
DOI: 10.1126/science.1137924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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