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Article

Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef

5 Apr 2007

Abstract excerpt

Nef is a virulence factor of HIV-1 and other primate lentiviruses that is crucial for rapid progression to AIDS. In cell culture, Nef increases the infectivity of HIV-1 progeny virions by an unknown mechanism. We now show that dynamin 2 (Dyn2), a key regulator of vesicular trafficking, is a binding partner of Nef that is required for its ability to increase viral infectivity. Dominant-negative Dyn2 or the...

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Identifiers

PMID: 17412836
DOI: 10.1073/pnas.0607622104

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