Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nef enhances HIV-1 infectivity via association with the virus assembly complex.

Virology - 10 Apr 2008

Qi Mingli, Aiken Christopher

Abstract excerpt

The HIV-1 accessory protein Nef enhances virus infectivity by facilitating an early post-entry step of infection. Nef acts in the virus producer cell, leading to a beneficial modification to HIV-1 particles. Nef itself is incorporated into HIV-1 particles, where it is cleaved by the viral protease during virion maturation. To probe the role of virion-associated Nef in HIV-1 infection, we generated a fusion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclophilin A
Share to Cyclosporine
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, nef

Share to HeLa Cells

Share to Multiprotein Complexes

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 18191978
DOI: 10.1016/j.virol.2007.12.001
PMCID: PMC2440657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nef enhances HIV-1 infectivity via association with the virus assembly complex.PMID 18191978Read ↗

The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.Semantic proximity Read ↗

Association of Nef with the Human Immunodeficiency Virus Type 1 CoreSemantic proximity Read ↗

Infectivity Enhancement by HIV-1 Nef Is Dependent on the Pathway of Virus Entry: Implications for HIV-Based Gene Transfer SystemsSemantic proximity Read ↗

HIV ‐1 Nef: Taking Control of Protein TraffickingSemantic proximity Read ↗

The activity of Nef on HIV-1 infectivitySemantic proximity Read ↗

How HIV Nef Proteins Hijack Membrane Traffic To Promote InfectionSemantic proximity Read ↗

Cell-dependent functional roles of HIV-1 Nef for virus replication (review).Semantic proximity Read ↗

Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase.Semantic proximity Read ↗

Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity.Semantic proximity Read ↗

Comparative Proteomic Analysis of HIV-1 Particles Reveals a Role for Ezrin and EHD4 in the Nef-Dependent Increase of Virus InfectivitySemantic proximity Read ↗

The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Nef Functions at the Level of Virus Entry by Enhancing Cytoplasmic Delivery of VirionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.