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Article

Loss of function of GATA3 induces basal-like mammary tumors

15 Dec 2021

Abstract excerpt

Purpose: GATA3 is a transcription factor essential for mammary luminal epithelial cell differentiation. Expression of GATA3 is absent or significantly reduced in basal-like breast cancers. Gata3 loss-of-function impairs cell proliferation, making it difficult to investigate the role of GATA3 deficiency in vivo. We previously demonstrated that CDK inhibitor p18 INK4c (p18) is a downstream target of GATA3 and...

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PMID: 34976209
DOI: 10.7150/thno.65796

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