Mutation of Tumor Suppressor Gene <i>Men1</i> Acutely Enhances Proliferation of Pancreatic Islet Cells

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN1), an inherited tumor syndrome affecting endocrine organs including pancreatic islets, results from mutation of the tumor suppressor gene Men1 that encodes protein menin. Although menin is known to be involved in regulating cell proliferation in vitro, it is not clear how menin regulates cell cycle and whether mutation of Men1 acutely promotes pancreatic islet cell...

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