Article
p27kip1: a new multiple endocrine neoplasia gene?
Neuroendocrinology - 1 Jan 2011
Marinoni Ilaria, Pellegata Natalia S
Abstract excerpt
Multiple endocrine neoplasias (MEN) are autosomal dominant disorders characterized by the occurrence of tumors in at least two endocrine glands. Two types of MEN syndromes have long been known: MEN type 1 (MEN1) and MEN type 2 (MEN2), associated with a different spectrum of affected organs. MEN1 and MEN2 are caused by germline mutations in the MEN1 tumor suppressor gene and the RET proto-oncogene, respectively....
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