Article
A Panel of Methylated MicroRNA Biomarkers for Identifying High-Risk Patients With Ulcerative Colitis-Associated Colorectal Cancer.
Gastroenterology - 1 Dec 2017
Toiyama Yuji, Okugawa Yoshinaga, Tanaka Koji, Araki Toshimitsu, Uchida Keiichi, Hishida Asahi, Uchino Motoi, Ikeuchi Hiroki, Hirota Seiichi, Kusunoki Masato, Boland C Richard, Goel Ajay
Abstract excerpt
BACKGROUND & AIMS: Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used to identify patients with ulcerative colitis (UC) who are at increased risk for colorectal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.