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Article

Significant impact of MTHFR C677T polymorphism on plasma homovanillic acid (HVA) levels among alcohol-dependent patients.

Addiction biology - 1 Mar 2007

Lutz Ulrich C, Batra Anil, Wiatr Gerlinde, Machicao Fausto, Kolb Werner, Maurer Sandra, Buchkremer Gerhard, Köhnke Michael D

Abstract excerpt

The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate. It plays a critical role in homocysteine metabolism. A high impact of MTHFR C677T polymorphism on plasma homocysteine levels has been observed among alcoholics. Recent studies indicate that homocysteine has toxic effects on dopaminergic neurons. Thus it lowers levels of homovanillic acid (HVA) in the striatal region...

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Source

Identifiers

PMID: 17407503
DOI: 10.1111/j.1369-1600.2006.00046.x

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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