Article
[Relationship between hyperhomocysteinemia and C677T polymorphism of methylene tetrahydrofolate reductase gene in a healthy Algerian population].
Annales de biologie clinique - 1 Jan 2000
Hambaba L, Abdessemed S, Yahia M, Laroui S, Rouabah F
Abstract excerpt
Plasmatic homocysteine concentration depends mostly on 5,10 methylene tetrahydrofolate reductase (MTHFR) polymorphisms, a key enzyme in folate metabolism. The most common point mutation C677T is associated to cardiovascular and neurological pathologies; its ethnic repartition is quite heterogenic. In the present study, we proposed to describe the genotypic and allelic frequencies of C677T polymorphism and its...
Topics
- Adolescent
- Adult
- Algeria
- Data Interpretation, Statistical
- Female
- Fluorescence Polarization Immunoassay
- Gene Frequency
- Genotype
- Homocysteine
- Humans
- Hyperhomocysteinemia
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Point Mutation
- Polymorphism, Genetic