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Article

Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Jul 2008

Ozbek Zeynep, Kucukali Cem Ismail, Ozkok Elif, Orhan Nurcan, Aydin Makbule, Kilic Gamze, Sazci Ali, Kara Ihsan

Abstract excerpt

We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. The c.677C>T and c.1298A>C polymorphisms in MTHFR were determined by polymerase chain reaction-restriction fragment length...

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Source

Identifiers

PMID: 18513846
DOI: 10.1016/j.pnpbp.2008.04.016

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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