Plasma Folate, Vitamin B<sub>12</sub>, and Total Homocysteine and Homozygosity for the C677T Mutation of the 5,10-Methylene Tetrahydrofolate Reductase Gene in Patients with Alzheimer’s Dementia

Abstract excerpt

BACKGROUND: Elevated total plasma homocysteine (tHcy) levels are considered a risk factor for cerebrovascular disease and may also play an important role in the pathogenesis of Alzheimer's disease (AD). High values of plasma tHcy and low levels of vitamin B(12) and folate are frequently present in AD patients. Moreover, the homozygous mutation (C677T) of the methylene tetrahydrofolate reductase (MTHFR) gene,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alcoholism and Thiamine Deficiency
• Share to Folate and B Vitamins Research
• Share to Nutrition, Genetics, and Disease