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Article

Protective effect against alcohol dependence of the thermolabile variant of MTHFR.

Drug and alcohol dependence - 1 Jul 2008

Saffroy Raphaël, Benyamina Amine, Pham Patrick, Marill Cathy, Karila Laurent, Reffas Maâmar, Debuire Brigitte, Reynaud Michel, Lemoine Antoinette

Abstract excerpt

BACKGROUND: Hyperhomocysteinemia is frequently observed in alcohol-dependent subjects, in particularly in those with marked withdrawal symptoms. The common C677T transition on the methylenetetrahydrofolate reductase (MTHFR) gene influences homocysteinemia. Our objective was to study the prevalence of the MTHFR C677T polymorphism in alcohol-dependent subjects and the influence of this polymorphism on symptoms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18328637
DOI: 10.1016/j.drugalcdep.2008.01.016

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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