Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells.

doi:10.1084/jem.175.3.843

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Article

Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells.

The Journal of experimental medicine - 1 Mar 1992

Glas R, Sturmhöfel K, Hämmerling G J, Kärre K, Ljunggren H G

Abstract excerpt

It has frequently been suggested that loss of beta 2-microglobulin (beta 2m) in tumor cells may lead to malignant progression due to escape from immunological recognition. Here, we directly tested the role of beta 2m expression in tumorigenicity. A beta 2 m loss mutant (C4.4-25-), selected from t...

Topics

Animals
Cell Separation
Flow Cytometry
Humans
Mice
Mice, Nude
Mutation
Phenotype
Transfection
Tumor Cells, Cultured
beta 2-Microglobulin

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