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Article

Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene

7 Aug 2000

Abstract excerpt

Leukotriene B(4) (LTB(4)) is a lipid mediator that activates leukocytes and is involved in host defense and inflammation. BLT1, a high-affinity receptor for LTB(4) (originally termed BLT), is expressed exclusively in inflammatory cells and is inducible in macrophages upon activation. The mechanisms of tissue-specific expression and induction of BLT1 are important for the understanding of mechanism of onset and...

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PMID: 10934229
DOI: 10.1084/jem.192.3.413

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