Article
Cancer immunoediting by the innate immune system in the absence of adaptive immunity.
The Journal of experimental medicine - 24 Sept 2012
O'Sullivan Timothy, Saddawi-Konefka Robert, Vermi William, Koebel Catherine M, Arthur Cora, White J Michael, Uppaluri Ravi, Andrews Daniel M, Ngiow Shin Foong, Teng Michele W L, Smyth Mark J, Schreiber Robert D, Bui Jack D
Abstract excerpt
Cancer immunoediting is the process whereby immune cells protect against cancer formation by sculpting the immunogenicity of developing tumors. Although the full process depends on innate and adaptive immunity, it remains unclear whether innate immunity alone is capable of immunoediting. To determine whether the innate immune system can edit tumor cells in the absence of adaptive immunity, we compared the...
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