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Article

Loop B is a major structural component of the 5-HT3 receptor.

Biophysical journal - 15 Dec 2008

Thompson A J, Lochner M, Lummis S C R

Abstract excerpt

The 5-HT(3) receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F). Here we have mutated 15 amino acid residues in and around loop B of the 5-HT(3) receptor (Ser-177 to Asn-191) to Ala or a residue with similar chemical properties. Changes in [3H]granisetron binding affinity (K(d)) and 5-HT...

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Identifiers

PMID: 18931259
DOI: 10.1529/biophysj.108.135624
PMCID: PMC2599823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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