Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modifiers of the Genotype-Phenotype Map: Hsp90 and Beyond.

PLoS biology - 1 Nov 2016

Schell Rachel, Mullis Martin, Ehrenreich Ian M

Abstract excerpt

Disruption of certain genes alters the heritable phenotypic variation among individuals. Research on the chaperone Hsp90 has played a central role in determining the genetic basis of this phenomenon, which may be important to evolution and disease. Key studies have shown that Hsp90 perturbation modifies the effects of many genetic variants throughout the genome. These modifications collectively transform the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epistasis, Genetic
Share to Genotype
Share to HSP90 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27832066
DOI: 10.1371/journal.pbio.2001015
PMCID: PMC5104472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modifiers of the Genotype-Phenotype Map: Hsp90 and Beyond.PMID 27832066Read ↗

The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Semantic proximity Read ↗

It's not magic - Hsp90 and its effects on genetic and epigenetic variation.Semantic proximity Read ↗

Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance.Semantic proximity Read ↗

Incapacitating the evolutionary capacitor: Hsp90 modulation of disease.Semantic proximity Read ↗

Genetic variation: HSP90 shapes human genetic variation.Semantic proximity Read ↗

Epigenetics is back! Hsp90 and phenotypic variation.Semantic proximity Read ↗

Molecular mechanisms of canalization: Hsp90 and beyond.Semantic proximity Read ↗

HSP90 Shapes the Consequences of Human Genetic VariationSemantic proximity Read ↗

Hsp90 at the crossroads of genetics and epigenetics.Semantic proximity Read ↗

Hsp90: A Global Regulator of the Genotype-to-Phenotype Map in Cancers.Semantic proximity Read ↗

Regulatory variants drive Hsp90’s effect on adaptationSemantic proximity Read ↗

Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.