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Article

MicroRNA Biogenesis Is Required for Mouse Primordial Germ Cell Development and Spermatogenesis

4 Mar 2008

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells express another type of small RNA, piwi-interacting RNAs (piRNAs). Although it has been clear that piRNAs play a role in repression of retrotransposons during spermatogenesis, the function of...

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PMID: 18320056
DOI: 10.1371/journal.pone.0001738

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