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Article

TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD?

Biochimica et biophysica acta - 1 Aug 2007

Hermosura Meredith C, Garruto Ralph M

Abstract excerpt

Recent findings implicating TRPM7 and TRPM2 in oxidative stress-induced neuronal death thrust these channels into the spotlight as possible therapeutic targets for neurodegenerative diseases. In this review, we describe how the functional properties of TRPM7 and TRPM2 are interconnected with calcium (Ca(2+)) and magnesium (Mg(2+)) homeostasis, oxidative stress, mitochondrial dysfunction, and immune mechanisms,...

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Source

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Identifiers

PMID: 17395433
DOI: 10.1016/j.bbadis.2007.02.008
PMCID: PMC1994999

Genes

TRPM2
TRPM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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