Article
A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders.
Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2005
Hermosura Meredith C, Nayakanti Hannah, Dorovkov Maxim V, Calderon Fernanda R, Ryazanov Alexey G, Haymer David S, Garruto Ralph M
Abstract excerpt
Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and...
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