Article
Significance of 5,10-methylenetetrahydrofolate reductase gene variants in acute lymphoblastic leukemia in Indian population: an experimental, computational and meta-analysis.
Leukemia & lymphoma - 1 May 2015
Bellampalli Ravishankara, Phani Nagaraja M, Bhat Kamalakshi G, Prasad Krishna, Bhaskaranand Nalini, Guruprasad Kanive P, Rai Padmalatha S, Satyamoorthy Kapaettu
Abstract excerpt
Acute lymphoblastic leukemia (ALL) arises due to several genetic alterations in progenitor cells, and methotrexate is frequently used as part of the treatment regimen. Although there is evidence for an effect of 5,10-methylenetetrahydrofolate reductase gene (MTHFR) C677T and A1298C variations on drug response in ALL, its risk association for ALL is still unresolved. In a case-control study of 203 patients with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.