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Article

Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia.

Leukemia & lymphoma - 1 Jun 2011

Canalle Renata, Silveira Vanessa S, Scrideli Carlos Alberto, Queiroz Rosane G P, Lopes Luiz Fernando, Tone Luiz Gonzaga

Abstract excerpt

The aim of this study was to evaluate the frequency of polymorphisms in the TYMS, XRCC1, and ERCC2 DNA repair genes in pediatric patients with acute lymphoblastic leukemia using polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP) approaches. The study was conducted in 206 patients and 364 controls from a Brazilian population. No significant differences were observed among the...

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Source

Identifiers

PMID: 21463130
DOI: 10.3109/10428194.2011.559672

Genes

TYMS
ERCC2
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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