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Article

Combining several polymorphisms of thymidylate synthase gene for pharmacogenetic analysis.

The pharmacogenomics journal - 1 Jan 2005

Krajinovic M, Costea I, Primeau M, Dulucq S, Moghrabi A

Abstract excerpt

Thymidylate synthase (TS) is an essential enzyme in proliferating cells and an important target for several chemotherapeutics. Several TS gene polymorphisms correlate with variable TS expression: a double (2R) and triple (3R) 28-bp repeat element, a G to C substitution of the 3R allele and a 6 bp variation in 3'UTR. We have previously shown that childhood acute lymphoblastic leukemia (ALL) patients who are...

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PMID: 16130010
DOI: 10.1038/sj.tpj.6500332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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