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Article

Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Jul 2005

Rengelshausen Jens, Banfield Maria, Riedel Klaus-Dieter, Burhenne Jürgen, Weiss Johanna, Thomsen Torben, Walter-Sack Ingeborg, Haefeli Walter E, Mikus Gerd

Abstract excerpt

OBJECTIVES: Constituents of St John's wort (SJW) in vivo induce the cytochrome P450 (CYP) isozymes 3A4, 2C9, and 2C19 but in vitro were shown to inhibit them. This study investigates both short- and long-term effects of SJW on the antifungal voriconazole, which is metabolized by these enzymes. ME...

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Identifiers

PMID: 16003289
DOI: 10.1016/j.clpt.2005.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16003289-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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