Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of genetic polymorphisms in the IL12-IFNG pathway with susceptibility to and prognosis of pulmonary tuberculosis in a Chinese population.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Oct 2010

Wang J, Tang S, Shen H

Abstract excerpt

Cytokines are crucial in activation of the cell-mediated immunity required for eliminating pathogens and controlling intracellular growth of Mycobacterium tuberculosis (TB). Genetic variants in the IL12-IFNG axis are hypothesized to be involved in the development and progression of TB. Genetic polymorphisms of rs2243115 and rs568408 in IL12A, rs3212227 in IL12B and rs2430561 in IFNG(+874) were detected in 522...

Topics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Join the communities discussing this publication.

China
Interferon-gamma
Interleukin-12 Subunit p40
Mycobacterium tuberculosis
Polymorphism, Genetic
Prognosis
Treatment Failure
Tuberculosis, Pulmonary

Source

Identifiers

PMID: 20544370
DOI: 10.1007/s10096-010-0985-0

Genes

IFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of genetic polymorphisms in the IL12-IFNG pathway with susceptibility to and prognosis of pulmonary tuberculosis in a Chinese population.PMID 20544370Read ↗

Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia.Semantic proximity Read ↗

Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis.Semantic proximity Read ↗

Association of IL12RB1 polymorphisms with susceptibility to and severity of tuberculosis in Japanese: a gene-based association analysis of 21 candidate genes.Semantic proximity Read ↗

Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population.Semantic proximity Read ↗

Association of IFNG gene polymorphisms with pulmonary tuberculosis but not with spinal tuberculosis in a Chinese Han population.Semantic proximity Read ↗

No Significant Effects of IL-6 and IL-13 Gene Variants on Tuberculosis Susceptibility in the Chinese Population.Semantic proximity Read ↗

Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection.Semantic proximity Read ↗

Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis.Semantic proximity Read ↗

Immune and inflammation-related gene polymorphisms and susceptibility to tuberculosis in Southern Xinjiang population: A case-control analysis.Semantic proximity Read ↗

IFNG and IFNGR1 polymorphisms are associated with tuberculosis: a case-control study.Semantic proximity Read ↗

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosisSemantic proximity Read ↗

Association study of polymorphisms in interferon-γ receptor genes with the risk of pulmonary tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.