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Article

Novel mutations in genes of the IL-12/IFN-γ axis cause susceptibility to tuberculosis.

Journal of infection and public health - 1 Sept 2023

Ahmad Sajjad, Ahmed Jawad, Khalifa Eman H, Khattak Farhad Ali, Khan Anwar Sheed, Farooq Syed Umar, Osman Sannaa M A, Salih Magdi M, Ullah Nadeem, Khan Taj Ali

Abstract excerpt

BACKGROUND: The IL-12/23/ISG15-IFN-γ pathway is the main immunological pathway for controlling intra-macrophagic microorganisms such as Mycobacteria, Salmonella, and Leishmania spp. Consequently, upon mutations in genes of the IL-12/23/ISG15-IFN-γ pathway cause increased susceptibility to intra-macrophagic pathogens, particularly to Mycobacteria. Therefore, the purpose of this study was to characterize the...

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PMID: 37437430
DOI: 10.1016/j.jiph.2023.06.005

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