Article
Polymorphisms of IFN-γ (+874A/T) and IL-12 (+1188A/C) in tuberculosis patients and their household contacts in Hyderabad, India.
Human immunology - 1 Jul 2016
Thada Shruthi, Ponnana Meenakshi, Sivangala Ramya, Joshi Lavanya, Alasandagutti Madhavilatha, Ansari Mohd Soheb Sadat, Schumann Ralf R, Valluri Vijayalakshmi, Gaddam Sumanlatha
Abstract excerpt
Several cytokine gene variants have shown to be associated with host susceptibility to infectious diseases including tuberculosis (TB). High rates of transmission were identified within household members of TB patients. In this study, we examined whether single nucleotide polymorphisms of IFN-γ +874A/T and IL-12 +1188A/C affect susceptibility to TB. Genomic DNA from patients with active disease, their household...
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