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Article

Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line

8 May 2018

Abstract excerpt

Mutations in PARK2 (parkin) can result in Parkinson's disease (PD). Parkin shares a bidirectional promoter with parkin coregulated gene (PACRG) and the transcriptional start sites are separated by only ~200 bp. Bidirectionally regulated genes have been shown to function in common biological pathways. Mice lacking parkin have largely failed to recapitulate the dopaminergic neuronal loss and movement impairments...

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PMID: 29760428
DOI: 10.1038/s41598-018-25766-1

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