Article
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.
The Journal of biological chemistry - 8 Feb 2008
Dou Hong, Theriot Corey A, Das Aditi, Hegde Muralidhar L, Matsumoto Yoshihiro, Boldogh Istvan, Hazra Tapas K, Bhakat Kishor K, Mitra Sankar
Abstract excerpt
NEIL1 and NEIL2 compose a family of DNA glycosylases that is distinct from that of the other two DNA glycosylases, OGG1 and NTH1, all of which are involved in repair of oxidized bases in mammalian genomes. That the NEIL proteins, unlike OGG1 and NTH1, are able to excise base lesions from single-stranded DNA regions suggests their preferential involvement in repair during replication and/or transcription. Previous...
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