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Article

Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis.

Cancer science - 1 May 2007

Mizumoto Yasunari, Kyo Satoru, Mori Noriko, Sakaguchi Junko, Ohno Satoshi, Maida Yoshiko, Hashimoto Manabu, Takakura Masahiro, Inoue Masaki

Abstract excerpt

The extracellular-regulated kinase (ERK) signaling pathway plays important roles in regulating the malignant potential of cancer cells in vitro. However, the effect of ERK signaling on the prognosis of human tumors is not clearly understood. The present study examined the expression of phosphorylated ERK1/2 (p-ERK1/2) as a hallmark of ERK activation, in relation to KRAS and BRAF mutations, in 63 endometrial...

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Source

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Identifiers

PMID: 17388789
DOI: 10.1111/j.1349-7006.2007.00445.x
PMCID: PMC11158071

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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