Article
Endometrial carcinomas with significant mucinous differentiation associated with higher frequency of k-ras mutations: a morphologic and molecular correlation study.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Sept 2013
Xiong Jinjun, He Mai, Jackson Cynthia, Ou Joyce J, Sung C James, Breese Virgina, Steinhoff Margaret M, Quddus M Ruhul, Tejada-Berges Trevor, Lawrence W Dwayne
Abstract excerpt
OBJECTIVES: K-ras gene product in the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway is critical in the development of certain types of malignancies. K-ras mutation-associated pancreatic and ovarian carcinomas often display mucinous differentiation. Previous studies have shown that k-ras mutation is found in 10% to 30% of endometrial carcinomas. We investigated k-ras mutations in...
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