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Article

KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer.

British journal of cancer - 4 Dec 2012

Birkeland E, Wik E, Mjøs S, Hoivik E A, Trovik J, Werner H M J, Kusonmano K, Petersen K, Raeder M B, Holst F, Øyan A M, Kalland K-H, Akslen L A, Simon R, Krakstad C, Salvesen H B

Abstract excerpt

BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma viral oncogenes homologue (KRAS) mutations have been reported to have an important role in tumorigenesis for human cancers, but there is limited knowledge regarding clinical relevance of KRAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23099803
DOI: 10.1038/bjc.2012.477
PMCID: PMC3516681

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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