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Article

Genetic-based dosing in orthopedic patients beginning warfarin therapy.

Blood - 1 Sept 2007

Millican Eric A, Lenzini Petra A, Milligan Paul E, Grosso Leonard, Eby Charles, Deych Elena, Grice Gloria, Clohisy John C, Barrack Robert L, Burnett R Stephen J, Voora Deepak, Gatchel Susan, Tiemeier Amy, Gage Brian F

Abstract excerpt

High variability in drug response and a narrow therapeutic index complicate warfarin therapy initiation. No existing algorithm provides recommendations on refining the initial warfarin dose based on genetic variables, clinical data, and international normalized ratio (INR) values. Our goal was to develop such an algorithm. We studied 92 patients undergoing primary or revision total hip or knee replacement. From...

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Share to Anticoagulants
Share to Arthroplasty, Replacement, Hip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthroplasty, Replacement, Knee

Share to Cytochrome P-450 CYP2C9

Share to International Normalized Ratio

Share to Mixed Function Oxygenases

Share to Vitamin K Epoxide Reductases

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Source

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Identifiers

PMID: 17387222
DOI: 10.1182/blood-2007-01-069609
PMCID: PMC1975838

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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