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Article

Predicting the warfarin maintenance dose in elderly inpatients at treatment initiation: accuracy of dosing algorithms incorporating or not VKORC1/CYP2C9 genotypes.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2011

Moreau C, Pautas E, Gouin-Thibault I, Golmard J-L, Mahé I, Mulot C, Loriot M-A, Siguret V

Abstract excerpt

BACKGROUND: Initiating warfarin is challenging in frail elderly patients because of low-dose requirements and interindividual variability. OBJECTIVES: We investigated whether incorporating VKORC1 and CYP2C9 genotype information in different models helped to predict the warfarin maintenance dose when added to clinical data and INR values at baseline (Day 0), and during warfarin induction. PATIENTS: We...

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Source

Identifiers

PMID: 21255252
DOI: 10.1111/j.1538-7836.2011.04213.x

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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