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Article

Gene-based warfarin dosing compared with standard of care practices in an orthopedic surgery population: a prospective, parallel cohort study.

Therapeutic drug monitoring - 1 Jun 2010

McMillin Gwendolyn A, Melis Roberta, Wilson Andrew, Strong Michael B, Wanner Nathan A, Vinik Russell G, Peters Christopher L, Pendleton Robert C

Abstract excerpt

Warfarin remains a difficult drug to manage due to a narrow therapeutic range and wide interindividual variability in dose requirements. The relationship between warfarin sensitivity and CYP2C9 and VKORC1 variants is strong, and is the basis for several proposed dosing algorithms. Here a gene-based dosing algorithm was compared with standard of care dosing in patients receiving warfarin to prevent venous...

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Share to Anticoagulants
Share to Arthroplasty, Replacement, Knee

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryl Hydrocarbon Hydroxylases

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Share to Cytochrome P-450 CYP2C9

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Source

Identifiers

PMID: 20386359
DOI: 10.1097/FTD.0b013e3181d925bb

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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