10 Years of Oral Anticoagulant Pharmacogenomics: What Difference will it Make? a Critical Appraisal

Abstract excerpt

Since the first report on warfarin pharmacogenetics in 1999, genetic variants have emerged as an important predictor of warfarin maintenance doses before therapy is initiated, raising expectations of greatly improved clinical outcomes. However, much of the information on warfarin sensitivity conveyed by genetic variants is captured by early international normalized ratio values traditionally used to guide dose...

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