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Minireview: Thioredoxin-Interacting Protein: Regulation and Function in the Pancreatic β-Cell

9 Jun 2014

Abstract excerpt

Pancreatic β-cells are responsible for insulin production, and loss of functional β-cell mass is now recognized as a critical step in the pathogenesis of both type 1 and type 2 diabetes. However, the factors controlling the life and death of the pancreatic β-cell have only started to be elucidated. Discovered as the top glucose-induced gene in a human islet microarray study 12 years ago, thioredoxin-interacting...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 24911120
DOI: 10.1210/me.2014-1095

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