Article
Associations of polymorphisms in TXNIP and gene-environment interactions with the risk of coronary artery disease in a Chinese Han population.
Journal of cellular and molecular medicine - 1 Dec 2016
Wang Xue-Bin, Han Ya-di, Zhang Shuai, Cui Ning-Hua, Liu Ze-Jin, Huang Zhu-Liang, Li Cong, Zheng Fang
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in thioredoxin-interacting protein (TXNIP) gene may modulate TXNIP expression, then increase the risk of coronary artery disease (CAD). In a two-stage case-control study with a total of 1818 CAD patients and 1963 controls, we genotyped three SNPs in TXNIP and found that the variant genotypes of SNPs rs7212 [odds ratio (OR) = 1.26, P = 0.001] and rs7211 (OR = 1.23, P = 0.005)...
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