Article
Polymorphic microRNA-target interactions: a novel source of phenotypic variation.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2006
Georges M, Clop A, Marcq F, Takeda H, Pirottin D, Hiard S, Tordoir X, Caiment F, Meish F, Bibé B, Bouix J, Elsen J M, Eychenne F, Laville E, Larzul C, Milenkovic D, Tobin J, Charlier And C
Abstract excerpt
Studying the muscular hypertrophy of Texel sheep by forward genetics, we have identified an A-to-G transition in the 3'UTR of the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle. This causes the down-regulation of this muscle-specific chalone and hence contributes to the muscular hypertrophy of Texel sheep. We demonstrate that...
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