Article
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.
Nature genetics - 1 Jul 2006
Clop Alex, Marcq Fabienne, Takeda Haruko, Pirottin Dimitri, Tordoir Xavier, Bibé Bernard, Bouix Jacques, Caiment Florian, Elsen Jean-Michel, Eychenne Francis, Larzul Catherine, Laville Elisabeth, Meish Françoise, Milenkovic Dragan, Tobin James, Charlier Carole, Georges Michel
Abstract excerpt
Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov x Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the...
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